PolySia: A new bioidentical structural substance  
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     ::  PROJECT      
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Enzymatic Production

  1. Schwarzer,D., Stummeyer,K., Haselhorst,T., Freiberger,F., Rode,B., Grove,M., Scheper,T., von Itzstein,M., Mühlenhoff,M., and Gerardy-Schahn,R. (2009). Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F. J. Biol. Chem..

  2. Oltmann-Norden,I., Galuska,S.P., Hildebrandt,H., Geyer,R., Gerardy-Schahn,R., Geyer,H., and Mühlenhoff,M. (2008). Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development. J. Biol. Chem., 283, 1463-1471.

  3. Galuska,S.P., Geyer,R., Gerardy-Schahn,R., Mühlenhoff,M., and Geyer,H. (2008). Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule (NCAM) in vivo. J. Biol. Chem., 283, 17-28.

  4. Freiberger,F., Claus,H., Günzel,A., Oltmann-Norden,I., Vionnet,J., Mühlenhoff,M., Vogel,U., Vann,W.F., Gerardy-Schahn,R., and Stummeyer,K. (2007). Biochemical characterization of a Neisseria meningitidis polysialyltransferase reveals novel functional motifs in bacterial sialyltransferases. Mol. Microbiol., 65, 1258-1275.

  5. Leiman,P.G., Battisti,A.J., Bowman,V.D., Stummeyer,K., Mühlenhoff,M., Gerardy-Schahn,R., Scholl,D., and Molineux,I.J. (2007). The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities. J. Mol. Biol., 371, 836-849.

  6. Haselhorst,T., Münster-Kühnel,A.K., Oschlies,M., Tiralongo,J., Gerardy-Schahn,R., and von Itzstein,M. (2007). Direct detection of ligand binding to Sepharose-immobilised protein using saturation transfer double difference (STDD) NMR spectroscopy. Biochem. Biophys. Res. Commun., 359, 866-870.

  7. Schwarzer,D., Stummeyer,K., Gerardy-Schahn,R., and Mühlenhoff,M. (2007). Characterization of a novel intramolecular chaperone domain conserved in endosialidases and other bacteriophage tail spike and fiber proteins. J. Biol. Chem., 282, 2821-2831.

  8. Haselhorst,T., Stummeyer,K., Mühlenhoff,M., Schaper,W., Gerardy-Schahn,R., and von Itzstein,M. (2006). Endosialidase NF appears to bind polySia DP5 in a helical conformation. Chembiochem., 7, 1875-1877.

  9. Stummeyer,K., Schwarzer,D., Claus,H., Vogel,U., Gerardy-Schahn,R., and Mühlenhoff,M. (2006). Evolution of bacteriophages infecting encapsulated bacteria: lessons from Escherichia coli K1-specific phages. Mol. Microbiol., 60, 1123-1135.

  10. Stummeyer,K., Dickmanns,A., Muhlenhoff,M., Gerardy-Schahn,R., and Ficner,R. (2005). Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F. Nat. Struct. Mol. Biol., 12, 90-96.


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